Will a 2200 pacesetter header fit a s-10 2200 engine?
if the s-10's engine is a 2200 as in made after 97 then yes it will fit the block just fine however the header will be turned the wrong way trying to route the exhaust under the block instead of towards the rear of the truck, check with some truck sites and you'll probably find a specific truck header or some more info about it.
J~